Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.50 |
| ▸ | GSK3A | P49840 | 4/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 8/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846684 | 0.85 | GSK3B (0.52) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL4400415 | 0.78 | GSK3B (0.63) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL7143730 | 0.77 | GSK3B (0.48) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL7104461 | 0.77 | GSK3B (0.54) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2914179 | 0.73 | GSK3B (0.47) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL4401829 | 0.73 | GSK3B (0.72) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL4399102 | 0.73 | GSK3B (0.67) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL10270545 | 0.73 | GSK3B (0.48) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL5089519 | 0.73 | GSK3B (0.58) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL5082585 | 0.72 | GSK3B (0.58) | GSK3BGSK3ACDK1CCNB2CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |