Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 4/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.47 |
| ▸ | HRH2 | P25021 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5038202 | 1.00 | LSS (0.58) | LSSSIGMAR1HRH3HRH2HRH1 | |
| SCHEMBL5035480 | 0.85 | LSS (0.67) | LSSHRH3 | |
| SCHEMBL5045528 | 0.85 | LSS (0.67) | LSSHRH3 | |
| SCHEMBL5038938 | 0.84 | LSS (0.66) | LSSHRH3 | |
| SCHEMBL5040185 | 0.77 | LSS (0.57) | LSS | |
| SCHEMBL5035552 | 0.76 | LSS (0.46) | LSSSIGMAR1 | |
| SCHEMBL5038468 | 0.75 | LSS (0.83) | LSSHRH3 | |
| SCHEMBL5038906 | 0.75 | LSS (0.83) | LSSHRH3 | |
| SCHEMBL7152745 | 0.75 | LSS (0.47) | LSS | |
| SCHEMBL5038908 | 0.75 | LSS (0.81) | LSSHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334094-A1 | CHOLESTEROL LOWERING BENZO[B]THIOPHENES AND BENZO[D]ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002036584-A1 | CHOLESTEROL LOWERING BENZO`B! THIOPHENES AND BENZO`D! ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-10 | — | — | WO | disclosed |