Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 12/20 | 0.57 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7169200 | 0.89 | ICAM1 (0.61) | ICAM1VCAM1HDAC6 | |
| SCHEMBL6747212 | 0.87 | ICAM1 (0.42) | ICAM1VCAM1HDAC6S1PR5PTGDR2 | |
| SCHEMBL7148447 | 0.86 | ICAM1 (0.63) | ICAM1VCAM1HDAC6 | |
| SCHEMBL6747386 | 0.76 | ICAM1 (0.45) | ICAM1VCAM1HDAC6 | |
| SCHEMBL6751985 | 0.73 | ICAM1 (0.47) | ICAM1VCAM1HDAC6 | |
| SCHEMBL6747579 | 0.73 | ICAM1 (1.00) | ICAM1VCAM1 | |
| Hydrochloric Acid SCHEMBL6749074 | 0.72 | ICAM1 (0.98) | ICAM1VCAM1 | |
| SCHEMBL8318910 | 0.71 | ICAM1 (0.96) | ICAM1VCAM1 | |
| Sulfuric Acid SCHEMBL6749617 | 0.71 | ICAM1 (0.93) | ICAM1VCAM1 | |
| SCHEMBL6747371 | 0.69 | ICAM1 (0.90) | ICAM1VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518423-B1 | These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and | EISAI CO., LTD. (JP) | 2003-02-11 | — | — | US | disclosed |
| EP-0934941-A1 | BENZOPIPERIDINE DERIVATIVES | Eisai Co., Ltd. (JP) | 1999-08-11 | — | — | EP | disclosed |