Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 12/20 | 0.73 |
| ▸ | F7 | P08709 | 12/20 | 0.73 |
| ▸ | PRSS1 | P07477 | 11/20 | 0.73 |
| ▸ | F10 | P00742 | 10/20 | 0.73 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.64 |
| ▸ | F3 | P13726 | 2/20 | 0.64 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.64 |
| ▸ | MRGPRX1 | Q96LB2 | 4/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7169846 | 1.00 | F2 (0.73) | F2F7PRSS1F10PRSS2 | |
| SCHEMBL5882979 | 0.93 | F2 (0.69) | F2F7PRSS1F10PRSS2 | |
| SCHEMBL7140881 | 0.89 | F2 (0.71) | F2F7PRSS1F10PRSS2 | |
| SCHEMBL7148242 | 0.89 | F7 (0.78) | F2F7PRSS1F10PRSS2 | |
| SCHEMBL7149324 | 0.89 | F7 (0.78) | F2F7PRSS1F10PRSS2 | |
| Acetic Acid SCHEMBL8128145 | 0.88 | F7 (0.76) | F2F7PRSS1F10PRSS2 | |
| Acetic Acid SCHEMBL8122925 | 0.88 | F7 (0.76) | F2F7PRSS1F10PRSS2 | |
| Acetic Acid SCHEMBL8127351 | 0.88 | F2 (0.69) | F2F7PRSS1F10PRSS2 | |
| SCHEMBL7144724 | 0.85 | F7 (1.00) | F2F7PRSS1F10PRSS2 | |
| SCHEMBL7144727 | 0.85 | F7 (1.00) | F2F7PRSS1F10PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921116-B1 | N-(4-carbamimido-phenyl)-glycine amide derivatives | HOFFMANN LA ROCHE (CH) | 2003-06-18 | — | — | EP | claimed |
| US-6140353-A | USED AS MEDICAMENTS FOR THE TREATMENT AND/OR PREVENTION OF THROMBOSES, APOPLEXY, CARDIAC INFARCTION, INFLAMMATION AND ARTERIOSCLEROSIS OR AS ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-10-31 | — | — | US | claimed |
| US-6140353-A | USED AS MEDICAMENTS FOR THE TREATMENT AND/OR PREVENTION OF THROMBOSES, APOPLEXY, CARDIAC INFARCTION, INFLAMMATION AND ARTERIOSCLEROSIS OR AS ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-10-31 | — | — | US | disclosed |