Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 9/20 | 0.61 |
| ▸ | F2 | P00734 | 8/20 | 0.61 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.61 |
| ▸ | F10 | P00742 | 7/20 | 0.61 |
| ▸ | F3 | P13726 | 4/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | F11 | P03951 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7149166 | 0.93 | F7 (0.63) | F7F2PRSS1F10F3 | |
| SCHEMBL7143824 | 0.91 | F7 (0.73) | F7F2PRSS1F10F3 | |
| SCHEMBL7146394 | 0.87 | F7 (0.62) | F7F2PRSS1F10F3 | |
| SCHEMBL7147639 | 0.87 | F7 (0.56) | F7F2PRSS1F10F3 | |
| SCHEMBL7150807 | 0.85 | F2 (0.82) | F7F2PRSS1F10F3 | |
| SCHEMBL7150811 | 0.85 | F2 (0.82) | F7F2PRSS1F10F3 | |
| SCHEMBL7150803 | 0.85 | F2 (0.82) | F7F2PRSS1F10F3 | |
| SCHEMBL7167218 | 0.85 | F2 (0.74) | F7F2PRSS1F10F3 | |
| SCHEMBL7167223 | 0.85 | F2 (0.74) | F7F2PRSS1F10F3 | |
| SCHEMBL7297747 | 0.85 | F2 (0.74) | F7F2PRSS1F10F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921116-B1 | N-(4-carbamimido-phenyl)-glycine amide derivatives | HOFFMANN LA ROCHE (CH) | 2003-06-18 | — | — | EP | disclosed |
| US-6140353-A | USED AS MEDICAMENTS FOR THE TREATMENT AND/OR PREVENTION OF THROMBOSES, APOPLEXY, CARDIAC INFARCTION, INFLAMMATION AND ARTERIOSCLEROSIS OR AS ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-10-31 | — | — | US | disclosed |
| EP-0921116-A1 | N-(4-carbamimido-phenyl)-glycine amide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-06-09 | — | — | EP | disclosed |