Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 9/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.56 |
| ▸ | F2 | P00734 | 7/20 | 0.56 |
| ▸ | F10 | P00742 | 7/20 | 0.56 |
| ▸ | F3 | P13726 | 4/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7148395 | 1.00 | F7 (0.56) | F7PRSS1F2F10F3 | |
| SCHEMBL7148384 | 1.00 | F7 (0.56) | F7PRSS1F2F10F3 | |
| SCHEMBL7148516 | 0.88 | F7 (0.61) | F7PRSS1F2F10F3 | |
| SCHEMBL7148524 | 0.88 | F7 (0.61) | F7PRSS1F2F10F3 | |
| SCHEMBL7148518 | 0.88 | F7 (0.61) | F7PRSS1F2F10F3 | |
| Hydrochloric Acid SCHEMBL8128859 | 0.88 | F2 (0.68) | F7PRSS1F2F10F3 | |
| Hydrochloric Acid SCHEMBL8128850 | 0.88 | F2 (0.68) | F7PRSS1F2F10F3 | |
| Hydrochloric Acid SCHEMBL7149378 | 0.88 | F2 (0.68) | F7PRSS1F2F10F3 | |
| SCHEMBL8119907 | 0.84 | F7 (0.57) | F7PRSS1F2F10F3 | |
| Hydrochloric Acid SCHEMBL8113471 | 0.83 | F7 (0.72) | F7PRSS1F2F10F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921116-B1 | N-(4-carbamimido-phenyl)-glycine amide derivatives | HOFFMANN LA ROCHE (CH) | 2003-06-18 | — | — | EP | disclosed |
| US-6140353-A | USED AS MEDICAMENTS FOR THE TREATMENT AND/OR PREVENTION OF THROMBOSES, APOPLEXY, CARDIAC INFARCTION, INFLAMMATION AND ARTERIOSCLEROSIS OR AS ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-10-31 | — | — | US | disclosed |
| EP-0921116-A1 | N-(4-carbamimido-phenyl)-glycine amide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-06-09 | — | — | EP | disclosed |