Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 14/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5038567 | 0.82 | LSS (0.69) | LSS | |
| SCHEMBL5035575 | 0.78 | LSS (1.00) | LSS | |
| SCHEMBL5045533 | 0.77 | LSS (0.69) | LSS | |
| SCHEMBL5045294 | 0.76 | LSS (0.70) | LSS | |
| SCHEMBL5035538 | 0.74 | LSS (0.74) | LSS | |
| SCHEMBL5040054 | 0.72 | LSS (0.78) | LSS | |
| SCHEMBL5038683 | 0.72 | LSS (0.58) | LSS | |
| SCHEMBL5038817 | 0.72 | LSS (0.64) | LSS | |
| SCHEMBL5038384 | 0.71 | LSS (0.72) | LSS | |
| SCHEMBL5038681 | 0.71 | LSS (0.66) | LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334094-A1 | CHOLESTEROL LOWERING BENZO[B]THIOPHENES AND BENZO[D]ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-13 | — | — | EP | claimed |
| WO-2002036584-A1 | CHOLESTEROL LOWERING BENZO`B! THIOPHENES AND BENZO`D! ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-10 | — | — | WO | claimed |