Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6745707 | 0.90 | HDAC6 (0.39) | HDAC6GAASCDHDAC3HDAC1 | |
| SCHEMBL6749663 | 0.89 | HDAC6 (0.39) | HDAC6SCDHDAC3HDAC1ICAM1 | |
| SCHEMBL7144509 | 0.86 | HDAC6 (0.35) | HDAC6SCDHDAC3HDAC1ICAM1 | |
| SCHEMBL6745905 | 0.83 | HDAC6 (0.37) | HDAC6 | |
| SCHEMBL7144505 | 0.83 | HDAC6 (0.35) | HDAC6SMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL6750372 | 0.81 | HDAC6 (0.36) | HDAC6ICAM1 | |
| SCHEMBL6745496 | 0.81 | HDAC6 (0.41) | HDAC6LMNAGAAMEN1PABPC1 | |
| SCHEMBL6745429 | 0.81 | HDAC6 (0.39) | HDAC6HDAC3HDAC1ICAM1 | |
| SCHEMBL6745421 | 0.80 | HDAC6 (0.39) | HDAC6HDAC3HDAC1ICAM1 | |
| SCHEMBL6750191 | 0.80 | HDAC6 (0.36) | HDAC6ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518423-B1 | These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and | EISAI CO., LTD. (JP) | 2003-02-11 | — | — | US | disclosed |