Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.67 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.67 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.67 |
| ▸ | KDR | P35968 | 3/20 | 0.67 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.67 |
| ▸ | ABL1 | P00519 | 2/20 | 0.67 |
| ▸ | RET | P07949 | 2/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.67 |
| ▸ | LTK | P29376 | 2/20 | 0.67 |
| ▸ | FLT3 | P36888 | 2/20 | 0.67 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.67 |
| ▸ | CDK7 | P50613 | 2/20 | 0.67 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.67 |
| ▸ | MST1R | Q04912 | 2/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.67 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.67 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.67 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.67 |
| ▸ | CDK8 | P49336 | 1/20 | 0.67 |
| ▸ | SYK | P43405 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7149696 | 1.00 | NTRK1 (0.67) | NTRK1NTRK3NTRK2KDRPRKD3 | |
| SCHEMBL7149690 | 1.00 | NTRK1 (0.67) | NTRK1NTRK3NTRK2KDRPRKD3 | |
| SCHEMBL7780481 | 0.82 | NTRK1 (0.83) | NTRK1NTRK3NTRK2KDRPRKD3 | |
| SCHEMBL7149051 | 0.80 | NTRK1 (0.64) | NTRK1NTRK3NTRK2KDRPRKD3 | |
| SCHEMBL7149059 | 0.80 | NTRK1 (0.64) | NTRK1NTRK3NTRK2KDRPRKD3 | |
| SCHEMBL7149055 | 0.80 | NTRK1 (0.64) | NTRK1NTRK3NTRK2KDRPRKD3 | |
| SCHEMBL5472269 | 0.80 | NTRK1 (1.00) | NTRK1NTRK3NTRK2KDRPRKD3 | |
| SCHEMBL14448937 | 0.80 | NTRK1 (1.00) | NTRK1NTRK3NTRK2KDRPRKD3 | |
| SCHEMBL5201532 | 0.80 | NTRK1 (1.00) | NTRK1NTRK3NTRK2KDRPRKD3 | |
| SCHEMBL7154038 | 0.79 | NTRK1 (0.44) | NTRK1NTRK3NTRK2KDRPRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6528653-B2 | E.g., 4,6-dihydro 4-(heterocyclic ring-methylene)thieno(2,3-b) pyrrolidin-5-one derivatives; tumor necrosis factor ) inhibitors; anticarcinogenic, -proliferative and -arthritic agents; Alzheimer's disease; cardiovascular disorders | HOFFMANN-LA ROCHE, INC. | 2003-03-04 | — | — | US | disclosed |