Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 15/20 | 0.48 |
| ▸ | AURKA | O14965 | 14/20 | 0.48 |
| ▸ | SRC | P12931 | 5/20 | 0.48 |
| ▸ | GSK3B | P49841 | 5/20 | 0.48 |
| ▸ | AURKC | Q9UQB9 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | LYN | P07948 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | HCK | P08631 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | MST1R | Q04912 | 2/20 | 0.41 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.41 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2205285 | 0.93 | AURKA (0.49) | AURKBAURKASRCGSK3BAURKC | |
| SCHEMBL2202873 | 0.85 | AURKB (0.56) | AURKBAURKASRCGSK3BAURKC | |
| SCHEMBL2202991 | 0.84 | AURKA (0.46) | AURKBAURKASRCGSK3BAURKC | |
| SCHEMBL2201915 | 0.81 | AURKA (0.58) | AURKBAURKASRCGSK3BAURKC | |
| SCHEMBL2203051 | 0.81 | AURKA (0.60) | AURKBAURKASRCGSK3BAURKC | |
| SCHEMBL2200331 | 0.81 | AURKA (0.58) | AURKBAURKASRCGSK3BAURKC | |
| SCHEMBL12430608 | 0.81 | AURKB (0.66) | AURKBAURKASRCGSK3BAURKC | |
| SCHEMBL2204454 | 0.79 | AURKA (0.73) | AURKBAURKASRCGSK3BAURKC | |
| SCHEMBL2203771 | 0.77 | AURKA (0.54) | AURKBAURKASRCGSK3BAURKC | |
| SCHEMBL2204021 | 0.77 | AURKB (0.47) | AURKBAURKASRCGSK3BAURKC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345925-A2 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002050065-A2 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-06-27 | — | — | WO | disclosed |