Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 5/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.33 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.33 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.32 |
| ▸ | WDR5 | P61964 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5040354 | 0.84 | LSS (0.58) | LSSMKNK1MKNK2 | |
| SCHEMBL5038769 | 0.84 | LSS (0.54) | LSSMKNK1MKNK2EPHX2KIF11 | |
| SCHEMBL5038283 | 0.83 | LSS (0.53) | LSSMKNK1MKNK2KIF11MAPK1 | |
| SCHEMBL7165185 | 0.82 | LSS (0.48) | LSSMKNK1MKNK2EPHX2KIF11 | |
| SCHEMBL5038562 | 0.82 | LSS (0.55) | LSSMKNK1MKNK2 | |
| SCHEMBL5038924 | 0.81 | LSS (0.56) | LSSMKNK1MKNK2KIF11MAPK1 | |
| SCHEMBL5035559 | 0.80 | LSS (0.58) | LSS | |
| SCHEMBL5045437 | 0.80 | LSS (0.61) | LSSMKNK1MKNK2MAPK1MAP2K4 | |
| SCHEMBL5035354 | 0.79 | LSS (0.46) | LSSMKNK1MKNK2KIF11TRPV1 | |
| SCHEMBL5045586 | 0.79 | LSS (0.50) | LSSMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334094-A1 | CHOLESTEROL LOWERING BENZO[B]THIOPHENES AND BENZO[D]ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002036584-A1 | CHOLESTEROL LOWERING BENZO`B! THIOPHENES AND BENZO`D! ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-10 | — | — | WO | disclosed |