SCHEMBL7152133

SCHEMBL7152133

CC(C)(C)[Si](C)(C)O[C@H]1CCC[C@]2(C)C(=O)CCC[C@@H]12

nearest known ligand 0.35

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PPM1D O15297 2/20 0.35
CYP19A1 P11511 16/20 0.34
HSD17B1 P14061 2/20 0.34
ESR1 P03372 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21613284 0.93 CYP19A1 (0.40) CYP19A1
SCHEMBL20244226 0.93 CYP19A1 (0.40) CYP19A1
SCHEMBL17180453 0.84 CYP19A1 (0.33) CYP19A1
SCHEMBL7150696 0.82 PPM1D (0.33) PPM1D
SCHEMBL7150700 0.82 PPM1D (0.33) PPM1D
SCHEMBL4159405 0.77 PPM1D (0.31) PPM1D
SCHEMBL4159409 0.77 PPM1D (0.31) PPM1D
SCHEMBL6851161 0.77 PPM1D (0.31) PPM1D
SCHEMBL9947147 0.72 CYP19A1 (0.44) CYP19A1
SCHEMBL12322074 0.72 CYP19A1 (0.44) CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0998455-B1 DIHOMO-SECO-CHOLESTANES WITH TWO UNSATURATED BONDS IN THE SIDE CHAIN HOFFMANN LA ROCHE (CH) 2003-10-01 EP disclosed
US-6153605-A Arylsecocholadiene derivatives HOFFMAN-LA ROCHE INC. (US) 2000-11-28 US disclosed
EP-0998455-A1 DIHOMO-SECO-CHOLESTANES WITH TWO UNSATURATED BONES IN THE SIDE CHAIN F.HOFFMANN-LA ROCHE AG (CH) 2000-05-10 EP disclosed
EP-0771789-B1 1 alpha, 26-dihydroxy-D-homo-vitamin D3 HOFFMANN LA ROCHE (CH) 2000-02-16 EP disclosed
EP-0977734-A2 ARYLSECOCHOLADIENE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2000-02-09 EP disclosed
US-5994569-A USEFUL IN THE TREATMENT OR PREVENTION OF VITAMIN D DEPENDENT DISORDERS AND OF IL-12-DEPENDENT AUTOIMMUNE DISEASES HOFFMANN-LA ROCHE INC. (US) 1999-11-30 US disclosed
US-5905074-A SKIN DISORDERS, ANTITUMOR AGENTS, VITAMIN D DERIVATIVES HOFFMANN-LA ROCHE INC. (US) 1999-05-18 US disclosed
WO-1999003828-A1 DIHOMO-SECO-CHOLESTANES WITH TWO UNSATURATED BONES IN THE SIDE CHAIN F.HOFFMANN-LA ROCHE AG (CH) 1999-01-28 WO disclosed
WO-1998047866-A2 ARYLSECOCHOLADIENE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1998-10-29 WO disclosed
EP-0771789-A1 1 alpha, 26-dihydroxy-D-homo-vitamin D3 F. HOFFMANN-LA ROCHE AG (CH) 1997-05-07 EP disclosed