SCHEMBL7153403

SCHEMBL7153403

CC(O)CCONC(=O)c1cc(Cl)c(F)c(F)c1Nc1ccc(I)cc1F.CCC(O)CCONC(=O)c1cc(Cl)c(F)c(F)c1Nc1ccc(I)cc1F

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAP2K1 Q02750 19/20 0.56
MAP2K2 P36507 4/20 0.56
PIM1 P11309 1/20 0.54
CAMK2B Q13554 1/20 0.54
BRAF P15056 1/20 0.54
MAPK1 P28482 1/20 0.54
MAP2K5 Q13163 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4851774 0.96 MAP2K1 (0.59) MAP2K1MAP2K2PIM1CAMK2BBRAF
SCHEMBL4857491 0.96 MAP2K1 (0.58) MAP2K1MAP2K2PIM1CAMK2BBRAF
SCHEMBL4861599 0.91 MAP2K1 (0.53) MAP2K1MAP2K2PIM1CAMK2BBRAF
SCHEMBL4853812 0.90 MAP2K1 (0.66) MAP2K1MAP2K2PIM1CAMK2BBRAF
SCHEMBL4851885 0.90 MAP2K1 (0.54) MAP2K1MAP2K2PIM1CAMK2BBRAF
SCHEMBL7047873 0.90 MAP2K1 (0.70) MAP2K1MAP2K2PIM1CAMK2BBRAF
SCHEMBL4860638 0.89 MEN1 (0.56) MAP2K1MAP2K2PIM1CAMK2BBRAF
SCHEMBL4854475 0.88 MEN1 (0.57) MAP2K1MAP2K2PIM1CAMK2B
SCHEMBL4864656 0.88 MAP2K1 (0.68) MAP2K1MAP2K2PIM1CAMK2BBRAF
SCHEMBL4861391 0.88 MAP2K1 (0.62) MAP2K1MAP2K2PIM1CAMK2BBRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1301472-A2 OXYGENATED ESTERS OF 4-IODO PHENYLAMINO BENZHYDROXAMIC ACIDS WARNER-LAMBERT COMPANY (US) 2003-04-16 EP disclosed
WO-2002006213-A2 OXYGENATED ESTERS OF 4-IODO PHENYLAMINO BENZHYDROXAMIC ACIDS WARNER-LAMBERT COMPANY (US) 2002-01-24 WO disclosed