Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.82 |
| ▸ | PDE4A | P27815 | 5/20 | 0.81 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.81 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.81 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.81 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.81 |
| ▸ | PDE2A | O00408 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL715378 | 0.90 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL714733 | 0.90 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7448642 | 0.82 | PDE5A (0.83) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL714965 | 0.82 | PDE5A (0.82) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8210864 | 0.79 | PDE5A (0.79) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7883021 | 0.79 | PDE5A (0.81) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5077752 | 0.77 | PDE5A (0.83) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5077648 | 0.76 | PDE5A (0.48) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4551320 | 0.70 | PDE5A (0.63) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10201626 | 0.69 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10238660-B2 | Organic compounds | INTRA-CELLULAR THERAPIES, INC. (US) | 2019-03-26 | — | — | US | disclosed |
| US-20180280396-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2018-10-04 | — | — | US | disclosed |
| US-10010553-B2 | Organic compounds | INTRA-CELLULAR THERAPIES, INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-20160375028-A1 | ORGANIC COMPOUNDS | FIENBERG ALLEN A (US) | 2016-12-29 | — | — | US | disclosed |
| US-9468637-B2 | Organic compounds | INTRA-CELLULAR THERAPIES, INC. (US) | 2016-10-18 | — | — | US | disclosed |
| US-9198924-B2 | Organic compounds | INTRA-CELLULAR THERAPIES, INC. (US) | 2015-12-01 | — | — | US | disclosed |
| EP-2434895-A1 | ORGANIC COMPOUNDS | Intra-Cellular Therapies, Inc. (US) | 2012-04-04 | — | — | EP | disclosed |
| US-20120053190-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC | 2012-03-01 | — | — | US | disclosed |
| WO-2010132127-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2010-11-18 | — | — | WO | disclosed |
| US-20100087450-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053190-A1 | ORGANIC COMPOUNDS | PDE5A, PDE4A, PDE3A | PDE5A 1/4885PDE4A 2/4885PDE4B 8/4885 |
| US-20180280396-A1 | ORGANIC COMPOUNDS | PDE5A, PDE4A, PDE3A | PDE5A 1/4885PDE4A 2/4885PDE4B 8/4885 |
| US-10010553-B2 | Organic compounds | PDE5A, PDE4A, PDE3A | PDE5A 1/4885PDE4A 2/4885PDE4B 8/4885 |
| US-20160375028-A1 | ORGANIC COMPOUNDS | PDE5A, PDE4A, PDE3A | PDE5A 1/4885PDE4A 2/4885PDE4B 8/4885 |
| US-20100087450-A1 | ORGANIC COMPOUNDS | PDE3A, PDE5A, PDE2A | PDE5A 2/4885PDE4A 8/4885PDE4B 9/4885 |
| US-10238660-B2 | Organic compounds | PDE5A, PDE4A, PDE3A | PDE5A 1/4885PDE4A 2/4885PDE4B 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.