Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 11/20 | 0.72 |
| ▸ | EGFR | P00533 | 7/20 | 0.68 |
| ▸ | KDR | P35968 | 7/20 | 0.68 |
| ▸ | FLT1 | P17948 | 1/20 | 0.68 |
| ▸ | KIF5B | P33176 | 6/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12227578 | 0.89 | RET (0.70) | RETEGFRKDRFLT1KIF5B | |
| SCHEMBL4110679 | 0.88 | RET (0.68) | RETEGFRKDRFLT1KIF5B | |
| SCHEMBL5864732 | 0.86 | KDR (0.69) | RETEGFRKDRFLT1KIF5B | |
| SCHEMBL7076160 | 0.84 | RET (1.00) | RETEGFRKDRFLT1KIF5B | |
| SCHEMBL8652761 | 0.83 | MAPK1 (0.80) | EGFRLCKMAPK1 | |
| SCHEMBL27698817 | 0.82 | KDR (0.61) | RETEGFRKDRFLT1KIF5B | |
| SCHEMBL6180170 | 0.82 | EGFR (0.76) | RETEGFRKDRFLT1KIF5B | |
| SCHEMBL12200787 | 0.82 | RET (0.74) | RETEGFRKDRFLT1KIF5B | |
| Hydrochloric Acid SCHEMBL6180124 | 0.81 | EGFR (0.74) | RETEGFRKDRFLT1KIF5B | |
| SCHEMBL7116313 | 0.81 | RET (0.73) | RETEGFRKDRFLT1KIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6638939-B2 | Anticancer agents | PARKER HUGHES INSTITUTE | 2003-10-28 | — | — | US | disclosed |