SCHEMBL7154356

SCHEMBL7154356

O=C(O)Cn1c(-c2cccc(Cl)c2)ncc(NC(=O)OCc2ccccc2)c1=O

nearest known ligand 0.59

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ELANE P08246 17/20 0.59
P2RX3 P56373 1/20 0.50
CASP1 P29466 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6556239 0.91 ELANE (0.64) ELANEP2RX3CASP1
SCHEMBL6085435 0.90 ELANE (0.67) ELANECASP1
SCHEMBL6556407 0.89 ELANE (0.69) ELANEP2RX3
SCHEMBL7152404 0.89 ELANE (0.54) ELANEP2RX3CASP1
SCHEMBL14548653 0.86 ELANE (0.46) ELANECASP1
SCHEMBL7155919 0.85 ELANE (0.54) ELANEP2RX3CASP1
SCHEMBL1937963 0.85 ELANE (0.70) ELANEP2RX3CASP1
SCHEMBL6558251 0.85 ELANE (0.69) ELANECASP1
SCHEMBL6556362 0.84 ELANE (0.63) ELANE
SCHEMBL6556218 0.84 ELANE (0.60) ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6528514-B1 Pyrimidin-4-one-5-amino-3-alkylcarboxamidomethyl compounds WELFIDE CORPORATION (JP) 2003-03-04 US disclosed
EP-1062949-A1 IgE ANTIBODY PRODUCTION INHIBITORS AND AUTOIMMUNE DISEASES INHIBITORS Welfide Corporation (JP) 2000-12-27 EP disclosed