Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 15/20 | 0.68 |
| ▸ | HCRTR2 | O43614 | 14/20 | 0.68 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5209730 | 0.88 | HCRTR1 (0.75) | HCRTR1HCRTR2MTNR1BMTNR1A | |
| SCHEMBL5212193 | 0.88 | HCRTR1 (0.75) | HCRTR1HCRTR2MTNR1BMTNR1A | |
| SCHEMBL5212071 | 0.88 | HCRTR1 (0.74) | HCRTR1HCRTR2MTNR1BMTNR1A | |
| SCHEMBL5208606 | 0.87 | HCRTR1 (0.73) | HCRTR1HCRTR2MTNR1BMTNR1A | |
| SCHEMBL7090351 | 0.85 | HCRTR1 (0.61) | HCRTR1HCRTR2MTNR1BMTNR1A | |
| SCHEMBL5210766 | 0.84 | HCRTR1 (0.74) | HCRTR1HCRTR2MTNR1BMTNR1A | |
| SCHEMBL5206563 | 0.84 | HCRTR1 (0.79) | HCRTR1HCRTR2MTNR1BMTNR1A | |
| SCHEMBL5207307 | 0.83 | HCRTR1 (0.78) | HCRTR1HCRTR2MTNR1BMTNR1A | |
| SCHEMBL5211349 | 0.83 | HCRTR1 (0.76) | HCRTR1HCRTR2MTNR1BMTNR1A | |
| SCHEMBL5210435 | 0.83 | HCRTR1 (0.76) | HCRTR1HCRTR2MTNR1BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347967-A1 | NOVEL BENZAZEPINES AND RELATED HETEROCYCLIC DERIVATIVES WHICH ARE USEFUL AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2003-10-01 | — | — | EP | claimed |
| WO-2002051838-A1 | NOVEL BENZAZEPINES AND RELATED HETEROCYCLIC DERIVATIVES WHICH ARE USEFUL AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2002-07-04 | — | — | WO | claimed |