Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.42 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.42 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.42 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1855243 | 0.83 | MEN1 (0.41) | MEN1KMT2APOLBKLK7NPC1 | |
| SCHEMBL5044120 | 0.81 | MEN1 (0.42) | MEN1KMT2APOLBKLK7NPC1 | |
| SCHEMBL5048609 | 0.78 | MEN1 (0.46) | MEN1KMT2APOLBKLK7NPC1 | |
| SCHEMBL6022062 | 0.77 | MEN1 (0.53) | MEN1KMT2APOLBKLK7NPC1 | |
| SCHEMBL5047813 | 0.77 | MEN1 (0.46) | MEN1KMT2APOLBKLK7NPC1 | |
| SCHEMBL1857107 | 0.75 | MEN1 (0.44) | MEN1KMT2APOLBKLK7NPC1 | |
| SCHEMBL5044001 | 0.75 | MEN1 (0.42) | MEN1KMT2APOLBKLK7NPC1 | |
| SCHEMBL6022041 | 0.74 | NPC1 (0.47) | MEN1KMT2APOLBNPC1RAB9A | |
| SCHEMBL4315038 | 0.74 | MEN1 (0.44) | MEN1KMT2AKLK7NPC1RAB9A | |
| SCHEMBL5044851 | 0.74 | MAPK14 (0.49) | SMN1; SMN2EPHX2HDAC2HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003064376-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-08-07 | — | — | WO | disclosed |