SCHEMBL715910

SCHEMBL715910

C[C@H](Nc1ncnc(N)n1)c1cc2cccc(Cl)c2nc1N1CCN(C(=O)N(C)C)CC1

nearest known ligand 0.40

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 10/20 0.40
KIT P10721 2/20 0.37
CNR2 P34972 2/20 0.36
CNR1 P21554 1/20 0.36
KRAS P01116 3/20 0.36
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL715911 1.00 PIK3CD (0.40) PIK3CDKITCNR2CNR1KRAS
SCHEMBL715035 0.92 CNR2 (0.44) PIK3CDKITCNR2CNR1KRAS
SCHEMBL715036 0.92 CNR2 (0.44) PIK3CDKITCNR2CNR1KRAS
SCHEMBL714203 0.90 MAPT (0.42) PIK3CDKITCNR2CNR1KRAS
SCHEMBL714202 0.90 MAPT (0.42) PIK3CDKITCNR2CNR1KRAS
SCHEMBL715148 0.89 PIK3CD (0.47) PIK3CDLMNA
SCHEMBL715149 0.89 PIK3CD (0.47) PIK3CDLMNA
SCHEMBL715305 0.87 PIK3CD (0.44) PIK3CDLMNA
SCHEMBL17530866 0.86 TNF (0.40) PIK3CDCNR2CNR1LMNA
SCHEMBL715573 0.86 TNF (0.40) PIK3CDCNR2CNR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2403847-B1 TRIAZINE DERIVATIVES AS KINASE INHIBITORS UCB BIOPHARMA SPRL (BE) 2016-03-02 EP claimed
US-8785628-B2 Triazine derivatives as kinase inhibitors UCB PHARMA, S.A. (BE) 2014-07-22 US claimed
EP-2403847-B1 TRIAZINE DERIVATIVES AS KINASE INHIBITORS UCB BIOPHARMA SPRL (BE) 2016-03-02 EP disclosed
US-8785628-B2 Triazine derivatives as kinase inhibitors UCB PHARMA, S.A. (BE) 2014-07-22 US disclosed
US-20120053167-A1 Triazine Derivatives as Kinase Inhibitors UCB PHARMA, S.A. (BE) 2012-03-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120053167-A1 Triazine Derivatives as Kinase Inhibitors MAP3K15, PI4KA, MAP3K20 PIK3CD 12/4885KIT 2070/4885CNR2 1488/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.