SCHEMBL715914

SCHEMBL715914

CC(Nc1ncnc(N)n1)c1cc2cccc(Cl)c2nc1N1CCC(NS(C)(=O)=O)CC1

nearest known ligand 0.44

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 1/20 0.44
CNR2 P34972 1/20 0.44
SMO Q99835 14/20 0.40
PIK3CD O00329 1/20 0.39
PRCP P42785 1/20 0.38
IRAK1 P51617 1/20 0.37
IRAK4 Q9NWZ3 1/20 0.37
ATR Q13535 1/20 0.37
ATRIP Q8WXE1 1/20 0.37
KIT P10721 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL715913 1.00 CNR1 (0.44) CNR1CNR2SMOPIK3CDPRCP
SCHEMBL713704 0.88 CNR1 (0.41) CNR1CNR2SMOPIK3CDIRAK1
SCHEMBL713703 0.88 CNR1 (0.41) CNR1CNR2SMOPIK3CDIRAK1
SCHEMBL715976 0.88 LRRK2 (0.44) CNR1CNR2SMOPIK3CD
SCHEMBL715977 0.88 LRRK2 (0.44) CNR1CNR2SMOPIK3CD
SCHEMBL715305 0.86 PIK3CD (0.44) PIK3CD
SCHEMBL713501 0.84 PIK3CD (0.40) CNR2PIK3CD
SCHEMBL717289 0.84 PIK3CD (0.40) CNR2PIK3CD
SCHEMBL714202 0.83 MAPT (0.42) CNR1CNR2PIK3CDKIT
SCHEMBL714203 0.83 MAPT (0.42) CNR1CNR2PIK3CDKIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2403847-B1 TRIAZINE DERIVATIVES AS KINASE INHIBITORS UCB BIOPHARMA SPRL (BE) 2016-03-02 EP claimed
US-8785628-B2 Triazine derivatives as kinase inhibitors UCB PHARMA, S.A. (BE) 2014-07-22 US claimed
US-8785628-B2 Triazine derivatives as kinase inhibitors UCB PHARMA, S.A. (BE) 2014-07-22 US disclosed
US-20120053167-A1 Triazine Derivatives as Kinase Inhibitors UCB PHARMA, S.A. (BE) 2012-03-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120053167-A1 Triazine Derivatives as Kinase Inhibitors MAP3K15, PI4KA, MAP3K20 CNR1 2238/4885CNR2 1488/4885SMO 3806/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.