Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 11/20 | 0.58 |
| ▸ | PTPRC | P08575 | 4/20 | 0.58 |
| ▸ | PTPN2 | P17706 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7160053 | 1.00 | PTPN1 (0.58) | PTPN1PTPRCPTPN2NPC1RAB9A | |
| SCHEMBL7160017 | 0.92 | PTPN1 (0.49) | PTPN1PTPRCPTPN2CYP4F2CYP4A11 | |
| SCHEMBL7166661 | 0.92 | PTPN1 (0.49) | PTPN1PTPRCPTPN2CYP4F2CYP4A11 | |
| SCHEMBL7169222 | 0.92 | PTPN1 (0.60) | PTPN1PTPRCPTPN2NPC1RAB9A | |
| SCHEMBL7165643 | 0.92 | PTPN1 (0.60) | PTPN1PTPRCPTPN2NPC1RAB9A | |
| SCHEMBL7161147 | 0.90 | PTPN1 (0.72) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7161152 | 0.90 | PTPN1 (0.72) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7166675 | 0.89 | PTPN1 (0.53) | PTPN1PTPRCPTPN2NPC1RAB9A | |
| SCHEMBL7163909 | 0.87 | PTPN1 (0.75) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7165640 | 0.86 | PTPN1 (0.57) | PTPN1PTPRCPTPN2MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583126-B2 | Treating diabetes, obesity, and diabetes-related diseases. | MERCK EROSST CANADA & CO. | 2003-06-24 | — | — | US | disclosed |
| US-20020052344-A1 | Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase IB (PTP-IB) | MERCK FROSST CANADA LTD. (CA) | 2002-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052344-A1 | Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase IB (PTP-IB) | PTPRO, PTPRC, PPM1B | PTPN1 17/4885PTPRC 2/4885PTPN2 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.