Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | PPARG | P37231 | 6/20 | 0.54 |
| ▸ | PPARA | Q07869 | 6/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7160752 | 1.00 | KDR (0.65) | KDRKDM4EALDH1A1PKMFFAR1 | |
| SCHEMBL6968517 | 0.90 | KDR (0.60) | KDRKDM4EALDH1A1FFAR1SMN1; SMN2 | |
| SCHEMBL6968514 | 0.90 | KDR (0.60) | KDRKDM4EALDH1A1FFAR1SMN1; SMN2 | |
| SCHEMBL6157414 | 0.87 | KDR (0.67) | KDRFFAR1MAPTPPARGPPARA | |
| SCHEMBL6960372 | 0.86 | KDR (0.63) | KDRFFAR1MAPTPPARGPPARA | |
| SCHEMBL6965135 | 0.86 | KDR (0.69) | KDRFFAR1MAPTPPARGPPARA | |
| SCHEMBL6965127 | 0.86 | KDR (0.69) | KDRFFAR1MAPTPPARGPPARA | |
| SCHEMBL6960376 | 0.86 | KDR (0.63) | KDRFFAR1MAPTPPARGPPARA | |
| SCHEMBL8983782 | 0.84 | KDR (0.66) | KDRFFAR1MAPTPPARGPPARA | |
| SCHEMBL8983784 | 0.84 | KDR (0.66) | KDRFFAR1MAPTPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552058-B1 | For therapy of diabetes or hyperlipidemia | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-04-22 | — | — | US | disclosed |
| US-6147099-A | USEFUL AS ANTI-DIABETICS OR HYPOLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5972970-A | COMPOUNDS SUCH AS 5-(3-(2-(2-(5-METHYL-2-PHENYL-4-OXAZOLYL) ETHOXYL-5-PYRIDYL)PROPYL)-2,4-OXAZOLIDINEDIONE; ADMINISTERING TO TREAT A MAMMAL SUFFERING FROM DIABETES OR HYPERLIPIDEMIA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-26 | — | — | US | disclosed |
| EP-0612743-B1 | Oxazolidinedione derivatives, their production and use in lowering blood sugar and lipid levels | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-09-10 | — | — | EP | disclosed |
| US-5665748-A | ANTIDIABETIC, HYPOLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-09-09 | — | — | US | disclosed |
| EP-0612743-A1 | Oxazolidinedione derivatives, their production and use in lowering blood sugar and lipid levels | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-08-31 | — | — | EP | disclosed |