SCHEMBL7162255

C[C@@H]1CN(Cc2ccc(F)cc2)[C@@H](C)CN1C(=O)COc1ccc(Cl)cc1C(N)=O.C[C@@H]1CN(Cc2ccc(F)cc2)[C@@H](C)CN1C(=O)COc1ccc(Cl)cc1NNCC(=O)O

nearest known ligand 0.70

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	CCR1	P32246	19/20	0.70

▸	FPR3	P25089	1/20	0.56

▸	GPR65	Q8IYL9	1/20	0.56

▸	GPR35	Q9HC97	1/20	0.56

▸	PTGDR2	Q9Y5Y4	1/20	0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL6928731	0.94	CCR1 (0.72)	CCR1FPR3GPR65GPR35PTGDR2
SCHEMBL6324947	0.89	CCR1 (0.84)	CCR1FPR3GPR65GPR35PTGDR2
SCHEMBL4588533	0.89	CCR1 (0.84)	CCR1FPR3GPR65GPR35PTGDR2
SCHEMBL5968158	0.89	CCR1 (0.84)	CCR1FPR3GPR65GPR35PTGDR2
SCHEMBL4588539	0.89	CCR1 (0.84)	CCR1FPR3GPR65GPR35PTGDR2
SCHEMBL6324954	0.89	CCR1 (0.84)	CCR1FPR3GPR65GPR35PTGDR2
SCHEMBL4588537	0.89	CCR1 (0.84)	CCR1FPR3GPR65GPR35PTGDR2
SCHEMBL4587143	0.83	CCR1 (0.79)	CCR1FPR3GPR65GPR35
SCHEMBL5972113	0.83	CCR1 (0.79)	CCR1FPR3GPR65GPR35
SCHEMBL6930875	0.83	CCR1 (0.79)	CCR1FPR3GPR65GPR35

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1423166-A2	NON-PEPTIDE CCR1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PROGRESSIVE RENAL FIBROSIS	SCHERING AKTIENGESELLSCHAFT (DE)	2004-06-02	—	—	EP	disclosed
WO-2003013656-A2	NON-PEPTIDE CCR1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PROGRESSIVE RENAL FIBROSIS	SCHERING AKTIENGESELLSCHAFT (DE)	2003-02-20	—	—	WO	disclosed