Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 9/20 | 0.70 |
| ▸ | BCR | P11274 | 8/20 | 0.70 |
| ▸ | NPC1 | O15118 | 7/20 | 0.67 |
| ▸ | RAB9A | P51151 | 7/20 | 0.67 |
| ▸ | GAA | P10253 | 4/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL714805 | 0.91 | ABL1 (0.72) | ABL1BCRNPC1RAB9AGAA | |
| SCHEMBL15629425 | 0.91 | ABL1 (0.57) | ABL1BCRNPC1RAB9AGAA | |
| SCHEMBL717044 | 0.91 | GAA (0.74) | ABL1BCRNPC1RAB9AGAA | |
| SCHEMBL715934 | 0.89 | GAA (0.65) | ABL1BCRNPC1RAB9AGAA | |
| SCHEMBL717030 | 0.89 | GAA (0.65) | ABL1BCRNPC1RAB9AGAA | |
| SCHEMBL14319701 | 0.89 | GAA (0.65) | ABL1BCRNPC1RAB9AGAA | |
| SCHEMBL5579274 | 0.89 | GAA (0.67) | ABL1BCRNPC1RAB9AGAA | |
| SCHEMBL716370 | 0.87 | GAA (0.63) | ABL1BCRNPC1RAB9AGAA | |
| SCHEMBL717539 | 0.86 | GAA (0.62) | ABL1BCRNPC1RAB9AGAA | |
| SCHEMBL14286286 | 0.86 | MEN1 (0.64) | ABL1BCRNPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4726486-B2 | — | — | 2011-07-20 | — | — | JP | claimed |
| CN-100491374-C | 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as C-KIT inhibitors | AB SCIENCE (FR) | 2009-05-27 | — | — | CN | claimed |
| US-20080255141-A1 | Modulators of signal transduction mediated by certain native and/or mutant tyrosine kinases; antiproliferative, anticarcinogenic, antiallergen, and antiinflammatory agents; metabolic and neurodegenerative disorders | AB SCIENCE | 2008-10-16 | — | — | US | claimed |
| US-7423055-B2 | e.g., 2-(2-methyl-5-amino)phenyl-4-(3-pyridyl)-thiazole; c-kit inhibitors; treating cell proliferative, metabolic, allergic, and degenerative disorders. | AB SCIENCE (FR) | 2008-09-09 | — | — | US | claimed |
| EP-1525200-B1 | 2-(3-AMINOARYL)AMINO-4-ARYL-THIAZOLES AND THEIR USE AS C-KIT INHIBITORS | AB SCIENCE (FR) | 2007-10-10 | — | — | EP | claimed |
| US-20050239852-A1 | 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors | AB SCIENCE (FR) | 2005-10-27 | — | — | US | claimed |
| CN-1684959-A | 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as C-KIT inhibitors | AB SCIENCE (FR) | 2005-10-19 | — | — | CN | claimed |
| EP-1525200-A1 | 2-(3-AMINOARYL)AMINO-4-ARYL-THIAZOLES AND THEIR USE AS C-KIT INHIBITORS | AB Science (FR) | 2005-04-27 | — | — | EP | claimed |
| US-20040110810-A1 | e.g., 2-(2-methyl-5-amino)phenyl-4-(3-pyridyl)-thiazole; c-kit inhibitors; treating cell proliferative, metabolic, allergic, and degenerative disorders. | AB SCIENCE | 2004-06-10 | — | — | US | claimed |
| WO-2004014903-A1 | 2-(3-AMINOARYL)AMINO-4-ARYL-THIAZOLES AND THEIR USE AS C-KIT INHIBITORS | AB SCIENCE (FR) | 2004-02-19 | — | — | WO | claimed |
| US-8993573-B2 | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors | AB SCIENCE (FR) | 2015-03-31 | — | — | US | disclosed |
| US-8993573-B2 | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors | AB SCIENCE (FR) | 2015-03-31 | — | — | US | disclosed |
| US-8835435-B2 | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors | AB SCIENCE (FR) | 2014-09-16 | — | — | US | disclosed |
| US-8835435-B2 | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors | AB SCIENCE (FR) | 2014-09-16 | — | — | US | disclosed |
| US-20140088108-A1 | 2-(3-AMINOARYL) AMINO-4-ARYL-THIAZOLES AND THEIR USE AS C-KIT INHIBITIORS | AB SCIENCE (FR) | 2014-03-27 | — | — | US | disclosed |
| CN-1684959-A | 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as C-KIT inhibitors | AB SCIENCE (FR) | 2005-10-19 | — | — | CN | disclosed |
| EP-1525200-A1 | 2-(3-AMINOARYL)AMINO-4-ARYL-THIAZOLES AND THEIR USE AS C-KIT INHIBITORS | AB Science (FR) | 2005-04-27 | — | — | EP | disclosed |
| WO-2004076693-A1 | TAILORED TREATMENT SUITABLE FOR DIFFERENT FORMS OF MASTOCYTOSIS | AB SCIENCE (FR) | 2004-09-10 | — | — | WO | disclosed |
| US-20040110810-A1 | e.g., 2-(2-methyl-5-amino)phenyl-4-(3-pyridyl)-thiazole; c-kit inhibitors; treating cell proliferative, metabolic, allergic, and degenerative disorders. | AB SCIENCE | 2004-06-10 | — | — | US | disclosed |
| WO-2004014903-A1 | 2-(3-AMINOARYL)AMINO-4-ARYL-THIAZOLES AND THEIR USE AS C-KIT INHIBITORS | AB SCIENCE (FR) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110810-A1 | e.g., 2-(2-methyl-5-amino)phenyl-4-(3-pyridyl)-thiazole; c-kit inhibitors; treating cell proliferative, metabolic, allergic, and degenerative disorders. | KIT, MAP3K2, CMA1 | ABL1 251/4885BCR 678/4885NPC1 2227/4885 |
| US-20140088108-A1 | 2-(3-AMINOARYL) AMINO-4-ARYL-THIAZOLES AND THEIR USE AS C-KIT INHIBITIORS | KIT, CHUK, CKS1B | ABL1 22/4885BCR 167/4885NPC1 2356/4885 |
| US-20050239852-A1 | 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors | KIT, CHUK, MAP3K2 | ABL1 36/4885BCR 232/4885NPC1 2045/4885 |
| US-20080255141-A1 | Modulators of signal transduction mediated by certain native and/or mutant tyrosine kinases; antiproliferative, anticarcinogenic, antiallergen, and antiinflammatory agents; metabolic and neurodegenerative disorders | KIT, MAP3K1, MAP3K6 | ABL1 176/4885BCR 389/4885NPC1 3150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.