Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 2/20 | 0.81 |
| ▸ | PDE5A | O76074 | 16/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | PDE2A | O00408 | 1/20 | 0.62 |
| ▸ | PDE6D | O43924 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | PDE9A | O76083 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | PDE6A | P16499 | 1/20 | 0.62 |
| ▸ | PDE6G | P18545 | 1/20 | 0.62 |
| ▸ | PDE4A | P27815 | 1/20 | 0.62 |
| ▸ | PDE6B | P35913 | 1/20 | 0.62 |
| ▸ | PDE6C | P51160 | 1/20 | 0.62 |
| ▸ | PDE1A | P54750 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31238756 | 0.90 | GUSB (1.00) | GUSBPDE5AKDM4EHPGDPDE1A | |
| SCHEMBL7160589 | 0.90 | GUSB (1.00) | GUSBPDE5AKDM4EHPGDPDE1A | |
| SCHEMBL7722832 | 0.87 | PDE5A (1.00) | GUSBPDE5AKDM4EMEN1PDE2A | |
| SCHEMBL7722716 | 0.87 | PDE5A (1.00) | GUSBPDE5AKDM4EMEN1PDE2A | |
| SCHEMBL7164572 | 0.86 | PDE5A (0.68) | GUSBPDE5AKDM4EMEN1PDE2A | |
| SCHEMBL7408452 | 0.85 | PDE5A (0.67) | GUSBPDE5AKDM4EMEN1PDE2A | |
| SCHEMBL7372948 | 0.84 | PDE5A (0.70) | GUSBPDE5AKDM4EMEN1PDE2A | |
| SCHEMBL11383679 | 0.84 | PDE5A (0.66) | GUSBPDE5AKDM4EMEN1PDE2A | |
| SCHEMBL7164672 | 0.84 | PDE5A (0.66) | GUSBPDE5AKDM4EMEN1PDE2A | |
| SCHEMBL7164509 | 0.84 | PDE5A (0.66) | GUSBPDE5AKDM4EMEN1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0371731-B1 | Quinazolinone derivatives | SMITH KLINE FRENCH LAB (GB) | 1994-04-20 | — | — | EP | claimed |
| EP-0371731-A2 | Quinazolinone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-06-06 | — | — | EP | claimed |
| JP-2193983-A | — | — | None | — | — | JP | disclosed |
| US-6562830-B1 | Compounds which prevent or induce the remission of existing precancerous or cancerous lesions or carcinomas would greatly reduce illness and death from cancer | CELL PATHWAYS, INC. | 2003-05-13 | — | — | US | disclosed |
| EP-0371731-B1 | Quinazolinone derivatives | SMITH KLINE FRENCH LAB (GB) | 1994-04-20 | — | — | EP | disclosed |
| US-5147875-A | 2-(SUBSTITUTED PHENYL)-4-OXO-QUINAZOLINES | SANSHIN KOGYO KABISHIKI KAISHA (JP) | 1992-09-15 | — | — | US | disclosed |
| US-5147875-A | 2-(SUBSTITUTED PHENYL)-4-OXO-QUINAZOLINES | SANSHIN KOGYO KABISHIKI KAISHA (JP) | 1992-09-15 | — | — | US | disclosed |
| JP-H02193983-A | QUINAZOLINE DERIVATIVE | SMITH KLINE LTD | 1990-07-31 | — | — | JP | disclosed |
| EP-0371731-A2 | Quinazolinone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-06-06 | — | — | EP | disclosed |