Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | BLM | P54132 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | RGS12 | O14924 | 2/20 | 0.45 |
| ▸ | GMNN | O75496 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | THPO | P40225 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7164087 | 0.90 | EGFR (0.49) | MAPTSMN1; SMN2MEN1CYP3A4KMT2A | |
| SCHEMBL5367191 | 0.83 | CYP3A4 (0.52) | MAPTSMN1; SMN2MEN1CYP3A4TSHR | |
| SCHEMBL5367189 | 0.83 | CYP3A4 (0.52) | MAPTSMN1; SMN2MEN1CYP3A4TSHR | |
| SCHEMBL5363578 | 0.75 | EGFR (0.43) | SMN1; SMN2MEN1CYP3A4KMT2AHSD17B10 | |
| SCHEMBL3243232 | 0.75 | MEN1 (0.57) | MAPTSMN1; SMN2MEN1CYP3A4TSHR | |
| SCHEMBL3243227 | 0.75 | MEN1 (0.57) | MAPTSMN1; SMN2MEN1CYP3A4TSHR | |
| SCHEMBL3242616 | 0.74 | MEN1 (0.62) | MAPTSMN1; SMN2MEN1CYP3A4TSHR | |
| SCHEMBL3242618 | 0.74 | MEN1 (0.62) | MAPTSMN1; SMN2MEN1CYP3A4TSHR | |
| SCHEMBL3242612 | 0.74 | MEN1 (0.62) | MAPTSMN1; SMN2MEN1CYP3A4TSHR | |
| SCHEMBL5367760 | 0.72 | EGFR (0.58) | MAPTSMN1; SMN2MEN1CYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596878-B2 | Protein kinase inhibitor compositio; used to treat cell proliferative disorders such as cancers charcterized by over-activity or inappropriate activity HER2 or EGFR. | YISSUM RESEARCH & DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY (IL) | 2003-07-22 | — | — | US | disclosed |