Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.44 |
| ▸ | HRH2 | P25021 | 16/20 | 0.44 |
| ▸ | HRH1 | P35367 | 16/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2967599 | 0.87 | KCNH2 (0.53) | HRH3HRH2HRH1KCNH2MEN1 | |
| SCHEMBL6989155 | 0.86 | HRH3 (0.48) | HRH3HRH2HRH1MEN1 | |
| SCHEMBL6094465 | 0.83 | HRH3 (0.56) | HRH3HRH2HRH1MEN1 | |
| SCHEMBL5965551 | 0.80 | HRH3 (0.48) | HRH3HRH2HRH1MEN1 | |
| SCHEMBL2970001 | 0.73 | KCNH2 (0.68) | HRH3HRH2HRH1KCNH2MEN1 | |
| SCHEMBL2966798 | 0.72 | KCNH2 (0.53) | HRH3HRH2HRH1KCNH2 | |
| SCHEMBL5965474 | 0.72 | HRH2 (0.43) | HRH3HRH2HRH1MEN1 | |
| SCHEMBL2966190 | 0.72 | KCNH2 (0.49) | HRH3HRH2HRH1KCNH2MEN1 | |
| SCHEMBL2963106 | 0.72 | KCNH2 (0.41) | HRH3HRH2HRH1KCNH2 | |
| SCHEMBL6989126 | 0.72 | KCNH2 (0.54) | HRH3HRH2HRH1KCNH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6559143-B1 | Class III electrophysiological activity, drugs which prolong the trans-membrane action potential duration and refractoriness, without affecting cardiac conduction | ASTRAZENECA AB (SE) | 2003-05-06 | — | — | US | claimed |