SCHEMBL7166140

SCHEMBL7166140

CC(CCO)CCNc1ccc(C(=O)c2sc(Nc3ccc(N4CCN(C)CC4)cc3)nc2N)cc1[N+](=O)[O-]

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 14/20 0.56
CCND1 P24385 14/20 0.56
CDK11A Q9UQ88 13/20 0.56
CCNT1 O60563 12/20 0.56
CDK9 P50750 12/20 0.56
CDK6 Q00534 12/20 0.56
CDK5 Q00535 2/20 0.50
LTK P29376 1/20 0.50
CLK2 P49760 1/20 0.50
GSK3A P49840 1/20 0.50
GSK3B P49841 1/20 0.50
CDK7 P50613 1/20 0.50
LIMK1 P53667 1/20 0.50
PRKCQ Q04759 1/20 0.50
TAOK1 Q7L7X3 1/20 0.50
CLK4 Q9HAZ1 1/20 0.50
ALK Q9UM73 1/20 0.50
DYRK1A Q13627 2/20 0.47
CDK5R1 Q15078 1/20 0.42
CCNA2 P20248 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5743032 0.93 CDK4 (0.61) CDK4CCND1CDK11ACCNT1CDK9
SCHEMBL5859407 0.90 CDK4 (0.61) CDK4CCND1CDK11ACCNT1CDK9
SCHEMBL5742538 0.88 CDK4 (0.58) CDK4CCND1CDK11ACCNT1CDK9
SCHEMBL5743262 0.86 CDK4 (0.56) CDK4CCND1CDK11ACCNT1CDK9
SCHEMBL5743265 0.86 CDK4 (0.56) CDK4CCND1CDK11ACCNT1CDK9
SCHEMBL5743966 0.82 CDK4 (0.66) CDK4CCND1CDK11ACCNT1CDK9
SCHEMBL5743671 0.81 CDK4 (0.64) CDK4CCND1CDK11ACCNT1CDK9
SCHEMBL5742133 0.80 CDK4 (0.67) CDK4CCND1CDK11ACCNT1CDK9
SCHEMBL5743442 0.79 CDK4 (0.55) CDK4CCND1CDK11ACCNT1CDK9
SCHEMBL5742039 0.78 CDK4 (0.61) CDK4CCND1CDK11ACCNT1CDK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1358169-A2 DIAMINOTHIAZOLES AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASE F. HOFFMANN-LA ROCHE AG (CH) 2003-11-05 EP disclosed
WO-2002057261-A2 DIAMINOTHIAZOLES AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASE F. HOFFMANN-LA ROCHE AG (CH) 2002-07-25 WO disclosed