Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 17/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 13/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3049798 | 0.96 | ADORA2A (0.49) | ADORA2AADORA1ADORA2BWNT3AMEN1 | |
| SCHEMBL3053434 | 0.89 | LRRK2 (0.47) | ADORA2AADORA1ADORA2BMEN1KMT2A | |
| SCHEMBL3048781 | 0.85 | ADORA2A (0.46) | ADORA2AADORA1ADORA2BWNT3AMEN1 | |
| SCHEMBL3044761 | 0.84 | ADORA2A (0.64) | ADORA2AADORA1ADORA2BMEN1KMT2A | |
| SCHEMBL7147830 | 0.83 | ADORA2A (0.59) | ADORA2AADORA1ADORA2BMEN1KMT2A | |
| SCHEMBL3049478 | 0.82 | LRRK2 (0.53) | ADORA2AADORA1ADORA2BMEN1KMT2A | |
| SCHEMBL3044476 | 0.82 | ADORA2A (0.48) | ADORA2AADORA1ADORA2BMEN1KMT2A | |
| SCHEMBL3053641 | 0.79 | ADORA2A (0.64) | ADORA2AADORA1ADORA2BMEN1KMT2A | |
| SCHEMBL3058336 | 0.78 | ADORA2A (0.60) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL3047856 | 0.77 | ADORA2A (0.69) | ADORA2AADORA1ADORA2BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303272-A2 | BENZOTHIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2001097786-A2 | BENZOTHIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-12-27 | — | — | WO | disclosed |