Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 20/20 | 0.61 |
| ▸ | FNTB | P49356 | 20/20 | 0.61 |
| ▸ | PGGT1B | P53609 | 20/20 | 0.61 |
| ▸ | DNAJA1 | P31689 | 2/20 | 0.50 |
| ▸ | KRAS | P01116 | 1/20 | 0.50 |
| ▸ | RAP1A | P62834 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7159363 | 0.93 | FNTA (0.59) | FNTAFNTBPGGT1BDNAJA1KRAS | |
| SCHEMBL7163347 | 0.92 | FNTA (0.57) | FNTAFNTBPGGT1BDNAJA1KRAS | |
| SCHEMBL7163806 | 0.91 | FNTA (0.58) | FNTAFNTBPGGT1BDNAJA1KRAS | |
| SCHEMBL7163163 | 0.91 | FNTA (0.59) | FNTAFNTBPGGT1BDNAJA1KRAS | |
| SCHEMBL7163126 | 0.91 | FNTA (0.56) | FNTAFNTBPGGT1BDNAJA1KRAS | |
| SCHEMBL7168707 | 0.91 | FNTA (0.60) | FNTAFNTBPGGT1BDNAJA1KRAS | |
| SCHEMBL7168671 | 0.90 | FNTA (0.58) | FNTAFNTBPGGT1BDNAJA1KRAS | |
| SCHEMBL7168362 | 0.89 | FNTA (0.57) | FNTAFNTBPGGT1BDNAJA1KRAS | |
| SCHEMBL7168708 | 0.88 | FNTA (0.65) | FNTAFNTBPGGT1BDNAJA1KRAS | |
| SCHEMBL7164687 | 0.88 | FNTA (0.56) | FNTAFNTBPGGT1BDNAJA1KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | claimed |