Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 5/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5043398 | 0.91 | LSS (0.44) | LSSMAPK14LTB4R | |
| SCHEMBL5035311 | 0.89 | LSS (0.41) | LSSSLC6A4MAPK14LTB4R | |
| SCHEMBL5038134 | 0.88 | LSS (0.39) | LSSMAPK14LTB4R | |
| SCHEMBL5045720 | 0.86 | LSS (0.52) | LSSMAPK14 | |
| SCHEMBL5038385 | 0.83 | LSS (0.58) | LSSMAPK14LTB4R | |
| SCHEMBL5040085 | 0.82 | MAPK14 (0.48) | LSSMAPK14LTB4R | |
| SCHEMBL5038212 | 0.81 | LSS (0.47) | LSSMAPK14LTB4R | |
| SCHEMBL7165515 | 0.78 | LSS (0.61) | LSS | |
| SCHEMBL7164552 | 0.75 | SMN1; SMN2 (0.34) | LSSMAPK14LTB4R | |
| SCHEMBL7181492 | 0.71 | LSS (0.58) | LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334094-A1 | CHOLESTEROL LOWERING BENZO[B]THIOPHENES AND BENZO[D]ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002036584-A1 | CHOLESTEROL LOWERING BENZO`B! THIOPHENES AND BENZO`D! ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-10 | — | — | WO | disclosed |