Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | MLYCD | O95822 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20315020 | 0.86 | CA14 (0.40) | CA14CA1CA2CA12CA9 | |
| SCHEMBL20326558 | 0.85 | CA1 (0.45) | CA14CA1CA2CA12CA9 | |
| SCHEMBL31011754 | 0.85 | CA14 (0.47) | CA14CA1CA12HDAC6HDAC1 | |
| SCHEMBL20326295 | 0.84 | CA12 (0.39) | CA14CA1CA2CA12CA9 | |
| SCHEMBL24323748 | 0.84 | SSTR4 (0.42) | CA14CA1CA2CA12CA9 | |
| SCHEMBL16428936 | 0.81 | CA14 (0.47) | CA14CA1CA2CA12CA9 | |
| SCHEMBL27035589 | 0.81 | CA14 (0.40) | CA14CA1CA2CA12CA9 | |
| SCHEMBL25969999 | 0.81 | CA14 (0.43) | CA14CA1CA2CA12CA9 | |
| SCHEMBL19750797 | 0.80 | CA1 (0.41) | CA14CA1CA2CA12CA9 | |
| SCHEMBL25124159 | 0.80 | CA14 (0.36) | CA14CA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0751774-B1 | HYPOCHOLESTEROLEMIC MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES | MERRELL PHARMA INC (US) | 2003-08-13 | — | — | EP | disclosed |
| EP-0745080-B1 | NOVEL MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMA INC (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5750521-A | Mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE | HOECHST MARION ROUSSEL INC. (US) | 1998-05-12 | — | — | US | disclosed |
| EP-0751774-A1 | HYPOCHOLESTEROLEMIC, ANTIATHEROSCLEROTIC AND HYPOTRIGLYCERIDEMIC MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES | MERRELL PHARMACEUTICALS INC. (US) | 1997-01-08 | — | — | EP | disclosed |
| EP-0750631-A1 | NOVEL MERCAPTOACETYLAMIDO 1,3,4,5-TETRAHYDRO-BENZO(C)AZEPIN-3-ONE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMACEUTICALS INC. (US) | 1997-01-02 | — | — | EP | disclosed |
| EP-0746566-A1 | NOVEL 2-SUBSTITUTED INDANE-2-MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMACEUTICALS INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0745080-A1 | NOVEL MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMACEUTICALS INC. (US) | 1996-12-04 | — | — | EP | disclosed |
| EP-0745081-A1 | NOVEL INDANE-2-MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL PHARMACEUTICALS INC. (US) | 1996-12-04 | — | — | EP | disclosed |
| WO-1995025519-A1 | HYPOCHOLESTEROLEMIC, ANTIATHEROSCLEROTIC AND HYPOTRIGLYCERIDEMIC MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES | MERRELL PHARMACEUTICALS INC. (US) | 1995-09-28 | — | — | WO | disclosed |
| WO-1995021857-A1 | NOVEL 2-SUBSTITUTED INDANE-2-MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMACEUTICALS INC. (US) | 1995-08-17 | — | — | WO | disclosed |
| WO-1995021839-A1 | NOVEL MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMACEUTICALS INC. (US) | 1995-08-17 | — | — | WO | disclosed |
| WO-1995021854-A1 | NOVEL MERCAPTOACETYLAMIDO 1,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-3-ONE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMACEUTICALS INC. (US) | 1995-08-17 | — | — | WO | disclosed |
| WO-1995021840-A1 | NOVEL INDANE-2-MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL PHARMACEUTICALS INC. (US) | 1995-08-17 | — | — | WO | disclosed |