Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 10/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | AGER | Q15109 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5040006 | 0.96 | LSS (0.44) | LSSKCNH2GCGR | |
| SCHEMBL7172439 | 0.89 | LSS (0.56) | LSSSMN1; SMN2 | |
| SCHEMBL5040439 | 0.87 | LSS (0.49) | LSSKCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL5035509 | 0.86 | LSS (0.59) | LSS | |
| SCHEMBL5045740 | 0.85 | LSS (0.45) | LSSAGER | |
| SCHEMBL7150154 | 0.84 | LSS (0.44) | LSSGCGRKDM4EALDH1A1CYP1A2 | |
| SCHEMBL7168884 | 0.83 | LSS (0.62) | LSSGCGRAGER | |
| SCHEMBL5035416 | 0.83 | LSS (0.58) | LSSKCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL5038850 | 0.82 | LSS (0.49) | LSSKCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL7149728 | 0.81 | LSS (0.41) | LSSKCNH2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334094-A1 | CHOLESTEROL LOWERING BENZO[B]THIOPHENES AND BENZO[D]ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002036584-A1 | CHOLESTEROL LOWERING BENZO`B! THIOPHENES AND BENZO`D! ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-10 | — | — | WO | disclosed |