Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | FNTA | P49354 | 2/20 | 0.31 |
| ▸ | FNTB | P49356 | 2/20 | 0.31 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7161945 | 0.89 | PRMT5 (0.32) | PRMT5WDR77DPP4 | |
| SCHEMBL6418028 | 0.81 | PRMT5 (0.32) | PRMT5WDR77FNTAFNTBPGGT1B | |
| SCHEMBL6471063 | 0.79 | FNTA (0.53) | FNTAFNTBPGGT1B | |
| SCHEMBL7166984 | 0.78 | PRMT5 (0.41) | PRMT5WDR77DPP4RIPK3RET | |
| SCHEMBL7166236 | 0.77 | FNTA (0.37) | FNTAFNTBPGGT1BMAOB | |
| SCHEMBL7167619 | 0.77 | PRMT5 (0.31) | PRMT5WDR77 | |
| SCHEMBL6448742 | 0.75 | FNTA (0.37) | FNTAFNTBPGGT1B | |
| SCHEMBL6411179 | 0.74 | PRMT5 (0.35) | PRMT5WDR77RET | |
| Hydrochloric Acid SCHEMBL6469829 | 0.73 | FNTA (0.38) | FNTAFNTBPGGT1B | |
| SCHEMBL7165181 | 0.72 | FNTA (0.37) | FNTAFNTBPGGT1BMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |