SCHEMBL716716

SCHEMBL716716

Cc1nc(N)nc(N[C@@H](C)c2cc3cccc(Cl)c3nc2N2CC[C@@H](O)C2)n1

nearest known ligand 0.37

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 3/20 0.37
CNR2 P34972 9/20 0.37
PIK3R2 O00459 1/20 0.36
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HRH4 Q9H3N8 1/20 0.36
SOS1 Q07889 2/20 0.36
TPH1 P17752 1/20 0.34
CHUK O15111 1/20 0.33
PTPN11 Q06124 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL716382 1.00 PIK3CD (0.37) PIK3CDCNR2PIK3R2KDM4EALDH1A1
SCHEMBL715637 0.90 PIK3CD (0.37) PIK3CDPIK3R2HRH4TPH1
SCHEMBL716761 0.90 PIK3CD (0.37) PIK3CDPIK3R2HRH4TPH1
SCHEMBL717289 0.88 PIK3CD (0.40) PIK3CDCNR2KDM4EALDH1A1SMN1; SMN2
SCHEMBL713501 0.88 PIK3CD (0.40) PIK3CDCNR2KDM4EALDH1A1SMN1; SMN2
SCHEMBL717891 0.85 LRRK2 (0.39) PIK3CDCNR2PIK3R2ALDH1A1HRH4
SCHEMBL717892 0.85 LRRK2 (0.39) PIK3CDCNR2PIK3R2ALDH1A1HRH4
SCHEMBL715761 0.85 PIK3R2 (0.39) PIK3R2HRH4TPH1
SCHEMBL715760 0.85 PIK3R2 (0.39) PIK3R2HRH4TPH1
SCHEMBL715265 0.84 MAPT (0.42) PIK3CDPIK3R2SMN1; SMN2SOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4342878-A1 ARGININE METHYLTRANSFERASE INHIBITOR AND USE THEREOF Cytosinlab Therapeutics Co., Ltd. (CN) 2024-03-27 EP claimed
EP-2403847-B1 TRIAZINE DERIVATIVES AS KINASE INHIBITORS UCB BIOPHARMA SPRL (BE) 2016-03-02 EP claimed
US-8785393-B2 Ophthalmic pharmaceutical compositions of DP2 receptor antagonists PANMIRA PHARMACEUTICALS, LLC (US) 2014-07-22 US claimed
US-8785628-B2 Triazine derivatives as kinase inhibitors UCB PHARMA, S.A. (BE) 2014-07-22 US claimed
EP-4342878-A1 ARGININE METHYLTRANSFERASE INHIBITOR AND USE THEREOF Cytosinlab Therapeutics Co., Ltd. (CN) 2024-03-27 EP disclosed
WO-2024054996-A1 METHODS FOR THE TREATMENT OF DEPRESSION AUTOBAHN THERAPEUTICS, INC. (US) 2024-03-14 WO disclosed
EP-2403847-B1 TRIAZINE DERIVATIVES AS KINASE INHIBITORS UCB BIOPHARMA SPRL (BE) 2016-03-02 EP disclosed
US-8785628-B2 Triazine derivatives as kinase inhibitors UCB PHARMA, S.A. (BE) 2014-07-22 US disclosed
US-20120053167-A1 Triazine Derivatives as Kinase Inhibitors UCB PHARMA, S.A. (BE) 2012-03-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120053167-A1 Triazine Derivatives as Kinase Inhibitors MAP3K15, PI4KA, MAP3K20 PIK3CD 12/4885CNR2 1488/4885PIK3R2 93/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.