Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | PDE6D | O43924 | 1/20 | 0.42 |
| ▸ | PDE6A | P16499 | 1/20 | 0.42 |
| ▸ | PDE6G | P18545 | 1/20 | 0.42 |
| ▸ | PDE6B | P35913 | 1/20 | 0.42 |
| ▸ | PDE6C | P51160 | 1/20 | 0.42 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7170790 | 0.91 | PDE5A (0.69) | PDE5AALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7167896 | 0.89 | PDE5A (0.67) | PDE5AALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7167673 | 0.87 | PDE5A (0.73) | PDE5AALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7164683 | 0.87 | PDE5A (0.75) | PDE5AALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7163487 | 0.85 | PDE5A (0.70) | PDE5AALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7170900 | 0.85 | PDE5A (0.74) | PDE5AALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7163184 | 0.84 | PDE5A (0.73) | PDE5AALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7160498 | 0.84 | PDE5A (0.75) | PDE5AALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7168464 | 0.84 | PDE5A (0.68) | PDE5AALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7168877 | 0.83 | PDE5A (0.77) | PDE5AALDH1A1MAPTLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576644-B2 | Treating sexual dysfunction including erectile dysfunction, diabetes melitus, gastrointestinal disorders, including gastric paresis and cardiovascular disorders; cyclic guanosine 3',5'-monophosphate (cGMP) | BRISTOL-MYERS SQUIBB CO. | 2003-06-10 | — | — | US | claimed |