Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 15/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 9/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 9/20 | 0.39 |
| ▸ | HTR3A | P46098 | 2/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7120479 | 1.00 | CHRNA7 (0.39) | CHRNA7CHRNB2CHRNA4HTR3AUSP30 | |
| SCHEMBL7122228 | 0.93 | CHRNA7 (0.41) | CHRNA7CHRNB2CHRNA4HTR3AUSP30 | |
| SCHEMBL7116924 | 0.89 | CHRNA7 (0.41) | CHRNA7CHRNB2CHRNA4HTR3AUSP30 | |
| SCHEMBL7224711 | 0.86 | CHRNA7 (0.42) | CHRNA7CHRNB2CHRNA4USP30 | |
| SCHEMBL7114479 | 0.85 | USP30 (0.41) | CHRNA7CHRNB2CHRNA4HTR3AUSP30 | |
| SCHEMBL7112823 | 0.85 | USP30 (0.41) | CHRNA7CHRNB2CHRNA4HTR3AUSP30 | |
| SCHEMBL7130507 | 0.85 | MAPK11 (0.45) | CHRNA7CHRNB2CHRNA4HTR3AUSP30 | |
| SCHEMBL7129596 | 0.85 | CHRNA7 (0.42) | CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL7114708 | 0.85 | PIM1 (0.38) | CHRNA7CHRNB2CHRNA4HTR3A | |
| SCHEMBL7129282 | 0.85 | HDAC3 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311505-A2 | QUINUCLIDINE-SUBSTITUTED HETEROARYL MOIETIES FOR TREATMENT OF DISEASE ( NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS ) | PHARMACIA & UPJOHN COMPANY (US) | 2003-05-21 | — | — | EP | claimed |
| WO-2002016355-A2 | QUINUCLIDINE-SUBSTITUTED HETEROARYL MOIETIES FOR TREATMENT OF DISEASE (NICOTINIC) ACETYLCHOLINE RECEPTOR LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2002-02-28 | — | — | WO | claimed |