Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7688432 | 0.85 | PDE4A (0.55) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7172514 | 0.84 | PDE4A (0.60) | PDE4AKCNH2TP53MAPT | |
| SCHEMBL7169134 | 0.84 | PDE4A (0.60) | PDE4AKCNH2TP53MAPT | |
| SCHEMBL7167992 | 0.84 | PDE4A (0.53) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7172524 | 0.84 | KCNH2 (0.53) | PDE4AKCNH2TP53MAPT | |
| SCHEMBL7171340 | 0.84 | PDE4A (0.71) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7169620 | 0.83 | PDE4A (0.58) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7690323 | 0.83 | PDE4A (0.61) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7169919 | 0.83 | PDE4A (0.62) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7169618 | 0.83 | PDE4A (0.55) | PDE4AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6541480-B2 | Controlling cytokines | SUNTORY LIMITED (JP) | 2003-04-01 | — | — | US | disclosed |
| US-6297248-B1 | 1-aryl-1,8-naphthylidin-4-one derivative as type IV phosphodiesterase inhibitor | SUNTORY LIMITED (JP) | 2001-10-02 | — | — | US | disclosed |