Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | KDR | P35968 | 1/20 | 0.66 |
| ▸ | EGFR | P00533 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 3/20 | 0.41 |
| ▸ | BLM | P54132 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7168120 | 1.00 | MAPT (0.66) | MAPTSMN1; SMN2KDREGFRKMT2A | |
| SCHEMBL7168119 | 1.00 | MAPT (0.66) | MAPTSMN1; SMN2KDREGFRKMT2A | |
| SCHEMBL5362540 | 0.84 | MAPT (0.78) | MAPTSMN1; SMN2KDREGFRKMT2A | |
| SCHEMBL5362536 | 0.84 | MAPT (0.78) | MAPTSMN1; SMN2KDREGFRKMT2A | |
| SCHEMBL5362544 | 0.84 | MAPT (0.78) | MAPTSMN1; SMN2KDREGFRKMT2A | |
| SCHEMBL1371456 | 0.80 | MAPT (1.00) | MAPTSMN1; SMN2KDREGFRKMT2A | |
| SCHEMBL1371460 | 0.80 | MAPT (1.00) | MAPTSMN1; SMN2KDREGFRKMT2A | |
| SCHEMBL1371458 | 0.80 | MAPT (1.00) | MAPTSMN1; SMN2KDREGFRKMT2A | |
| SCHEMBL5373092 | 0.74 | MAPT (0.67) | MAPTSMN1; SMN2KDREGFRKMT2A | |
| SCHEMBL5373095 | 0.74 | MAPT (0.67) | MAPTSMN1; SMN2KDREGFRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596878-B2 | Protein kinase inhibitor compositio; used to treat cell proliferative disorders such as cancers charcterized by over-activity or inappropriate activity HER2 or EGFR. | YISSUM RESEARCH & DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY (IL) | 2003-07-22 | — | — | US | claimed |