Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 3/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2963414 | 0.89 | KCNH2 (0.56) | KCNH2POLBL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL6622531 | 0.88 | POLB (0.48) | KCNH2POLBL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL6097129 | 0.86 | POLB (0.50) | KCNH2POLBL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL4425025 | 0.79 | KCNH2 (0.47) | KCNH2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6094455 | 0.79 | KDM4E (0.61) | KCNH2L3MBTL1KDM4EALDH1A1HRH2 | |
| SCHEMBL2964372 | 0.79 | KCNH2 (0.63) | KCNH2POLBL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL2968137 | 0.78 | HRH1 (0.54) | KCNH2HRH2HRH1HRH3MEN1 | |
| SCHEMBL7035874 | 0.78 | POLB (0.52) | KCNH2POLBL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL7248379 | 0.77 | POLB (0.46) | KCNH2POLBL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL6094259 | 0.76 | POLB (0.54) | KCNH2POLBL3MBTL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6559143-B1 | Class III electrophysiological activity, drugs which prolong the trans-membrane action potential duration and refractoriness, without affecting cardiac conduction | ASTRAZENECA AB (SE) | 2003-05-06 | — | — | US | claimed |