Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | APEX1 | P27695 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.42 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.42 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9818964 | 0.90 | MAPT (0.67) | MAPTPOLBAPEX1SMN1; SMN2BCL2L1 | |
| SCHEMBL2326248 | 0.89 | MAPT (0.64) | MAPTPOLBAPEX1SMN1; SMN2BCL2L1 | |
| SCHEMBL13749241 | 0.88 | MAPT (0.67) | MAPTPOLBAPEX1SMN1; SMN2BCL2L1 | |
| SCHEMBL13720687 | 0.85 | MAPT (0.64) | MAPTPOLBAPEX1SMN1; SMN2BCL2L1 | |
| SCHEMBL1020458 | 0.85 | MAPT (0.61) | MAPTPOLBAPEX1SMN1; SMN2BCL2L1 | |
| SCHEMBL4008254 | 0.84 | MAPT (0.60) | MAPTPOLBAPEX1SMN1; SMN2BCL2L1 | |
| SCHEMBL14071618 | 0.84 | MAPT (0.63) | MAPTPOLBAPEX1SMN1; SMN2BCL2L1 | |
| SCHEMBL7213711 | 0.84 | MAPT (0.63) | MAPTPOLBAPEX1SMN1; SMN2BCL2L1 | |
| SCHEMBL12568260 | 0.84 | APEX1 (0.75) | MAPTPOLBAPEX1SMN1; SMN2BCL2L1 | |
| SCHEMBL1471963 | 0.84 | MAPT (0.60) | MAPTPOLBAPEX1SMN1; SMN2BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003007955-A2 | BIPHENYL APURINIC/APYRIMIDINIC SITE ENDONUCLEASE INHIBITORS TO TREAT CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2003-01-30 | — | — | WO | claimed |
| WO-2003007955-A2 | BIPHENYL APURINIC/APYRIMIDINIC SITE ENDONUCLEASE INHIBITORS TO TREAT CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2003-01-30 | — | — | WO | disclosed |