Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3607588 | 0.90 | MME (0.47) | MMEKCNN4NPSR1KIF11POLB | |
| SCHEMBL2742288 | 0.86 | KCNN4 (0.46) | MMEKCNN4NPSR1RAB9AKIF11 | |
| SCHEMBL29908038 | 0.85 | NPSR1 (0.43) | KCNN4NPSR1KIF11CNR1CNR2 | |
| SCHEMBL13726857 | 0.83 | NAALAD2 (0.51) | NPSR1 | |
| SCHEMBL4627986 | 0.83 | NAALAD2 (0.51) | NPSR1 | |
| SCHEMBL28500174 | 0.83 | NPSR1 (0.42) | MMEKCNN4NPSR1KIF11CNR1 | |
| SCHEMBL4627982 | 0.83 | NAALAD2 (0.51) | NPSR1 | |
| SCHEMBL29478394 | 0.83 | NPSR1 (0.42) | MMEKCNN4NPSR1KIF11CNR1 | |
| Diethylamine SCHEMBL30092414 | 0.83 | KCNN4 (0.41) | KCNN4NPSR1KIF11LMNAPOLB | |
| Diethylamine SCHEMBL28968612 | 0.83 | KCNN4 (0.41) | KCNN4NPSR1KIF11LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311488-A1 | SUBSTITUTED IMIDAZOLES AS TAFIA INHIBITORS | Pfizer Limited (GB) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002014285-A1 | SUBSTITUTED IMIDAZOLES AS TAFIA INHIBITORS | PFIZER LIMITED (GB) | 2002-02-21 | — | — | WO | disclosed |