Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | FCGR3B | O75015 | 1/20 | 0.37 |
| ▸ | FCGR1A | P12314 | 1/20 | 0.37 |
| ▸ | FCGR2A | P12318 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1624629 | 0.92 | MEN1 (0.51) | MEN1KMT2AAGPAT2RAB9AMAPK1 | |
| SCHEMBL7017813 | 0.85 | MEN1 (0.49) | MEN1KMT2ARAB9AMAPK1KDM4E | |
| SCHEMBL3950718 | 0.81 | KMT2A (0.50) | MEN1KMT2ARAB9AKDM4EHPGD | |
| SCHEMBL1625442 | 0.80 | MEN1 (0.50) | MEN1KMT2ARAB9AMAPK1KDM4E | |
| SCHEMBL1625505 | 0.79 | MEN1 (0.49) | MEN1KMT2ARAB9AKDM4EHPGD | |
| SCHEMBL1626147 | 0.79 | MEN1 (0.49) | MEN1KMT2ARAB9AKDM4EHPGD | |
| SCHEMBL1625684 | 0.79 | AGPAT2 (0.42) | MEN1KMT2AAGPAT2PDE4BKDM4E | |
| SCHEMBL1624628 | 0.74 | MEN1 (0.43) | MEN1KMT2ARAB9AMAPK1KDM4E | |
| SCHEMBL1623514 | 0.72 | MEN1 (0.41) | MEN1KMT2AAGPAT2RAB9APDE4B | |
| SCHEMBL4561259 | 0.72 | MEN1 (0.41) | MEN1KMT2ARAB9AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326606-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032422-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-04-25 | — | — | WO | disclosed |