Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.46 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.41 |
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4942358 | 0.90 | SMARCA2 (0.51) | SMARCA2SMARCA4PBRM1IKBKBTRPV3 | |
| SCHEMBL7200730 | 0.86 | SMARCA2 (0.43) | SMARCA2SMARCA4PBRM1IKBKBTRPV3 | |
| SCHEMBL4947268 | 0.85 | SMARCA2 (0.51) | SMARCA2SMARCA4PBRM1IKBKBTRPV3 | |
| SCHEMBL7015204 | 0.84 | SMARCA2 (0.49) | SMARCA2SMARCA4PBRM1IKBKBTRPV3 | |
| SCHEMBL14028507 | 0.84 | SMARCA2 (0.49) | SMARCA2SMARCA4PBRM1IKBKBTRPV3 | |
| SCHEMBL14046508 | 0.83 | SMARCA2 (0.54) | SMARCA2SMARCA4PBRM1IKBKBTRPV3 | |
| SCHEMBL14028510 | 0.82 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1IKBKBTRPV3 | |
| SCHEMBL4947972 | 0.81 | SMARCA2 (0.51) | SMARCA2SMARCA4PBRM1IKBKBTRPV3 | |
| SCHEMBL4938233 | 0.81 | SMARCA2 (0.51) | SMARCA2SMARCA4PBRM1IKBKBTRPV3 | |
| SCHEMBL4947201 | 0.81 | SMARCA2 (0.51) | SMARCA2SMARCA4PBRM1IKBKBTRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326856-A1 | PYRIDINE DERIVATIVES WITH IKB-KINASE (IKK-BETA) INHIBITING ACTIVITY | Bayer Aktiengesellschaft (DE) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002024679-A1 | PYRIDINE DERIVATIVES WITH IKB-KINASE (IKK-β) INHIBITING ACTIVITY | BAYER AKTIENGESELLSCHAFT (DE) | 2002-03-28 | — | — | WO | disclosed |