Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 18/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.66 |
| ▸ | PDE4A | P27815 | 12/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.66 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.55 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2888216 | 1.00 | PDE4D (0.66) | PDE4DPDE4BPDE4APDE4CPDE7B | |
| SCHEMBL4011641 | 0.89 | PDE4D (0.63) | PDE4DPDE4BPDE4APDE4CPDE7B | |
| SCHEMBL6435630 | 0.88 | PDE4D (0.61) | PDE4DPDE4BPDE4APDE4CPDE7B | |
| SCHEMBL2881703 | 0.88 | PDE4D (0.61) | PDE4DPDE4BPDE4APDE4CPDE7B | |
| SCHEMBL6435624 | 0.88 | PDE4D (0.61) | PDE4DPDE4BPDE4APDE4CPDE7B | |
| SCHEMBL2886875 | 0.85 | PDE4D (0.63) | PDE4DPDE4BPDE4APDE4CPDE7B | |
| SCHEMBL5875874 | 0.85 | PDE4D (0.63) | PDE4DPDE4BPDE4APDE4CPDE7B | |
| SCHEMBL2887808 | 0.84 | PDE7B (0.73) | PDE4DPDE4BPDE4APDE4CPDE7B | |
| SCHEMBL5528256 | 0.84 | PDE7B (0.73) | PDE4DPDE4BPDE4APDE4CPDE7B | |
| SCHEMBL2889809 | 0.84 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4CPDE7B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362044-A1 | PHTHALAZINONE-PIPERIDINO-DERIVATIVES AS PDE4 INHIBITORS | ALTANA Pharma AG (DE) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002064584-A1 | PHTHALAYINONE-PIPERIDINO-DERIVATIVES AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2002-08-22 | — | — | WO | disclosed |