Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7175391 | 1.00 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7189683 | 0.91 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7189679 | 0.91 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7436872 | 0.89 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7196891 | 0.86 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7874339 | 0.86 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7886295 | 0.86 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6172536 | 0.85 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8509453 | 0.84 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7182040 | 0.83 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071645-A4 | PHOSPHODIESTERASE ISOENZYME DENOMINATED 4 (PDE 4) INHIBITING COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2003-04-02 | — | — | EP | claimed |
| EP-1071645-A1 | PHOSPHODIESTERASE ISOENZYME DENOMINATED 4 (PDE 4) INHIBITING COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-31 | — | — | EP | claimed |
| US-6172118-B1 | Compounds | SMITHKLINE BEECHAM CORPORATION | 2001-01-09 | — | — | US | claimed |
| WO-1999052847-A1 | PHOSPHODIESTERASE ISOENZYME DENOMINATED 4 (PDE 4) INHIBITING COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-21 | — | — | WO | claimed |
| EP-1071645-A4 | PHOSPHODIESTERASE ISOENZYME DENOMINATED 4 (PDE 4) INHIBITING COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2003-04-02 | — | — | EP | disclosed |
| EP-1071645-A1 | PHOSPHODIESTERASE ISOENZYME DENOMINATED 4 (PDE 4) INHIBITING COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-31 | — | — | EP | disclosed |
| US-6172118-B1 | Compounds | SMITHKLINE BEECHAM CORPORATION | 2001-01-09 | — | — | US | disclosed |
| WO-1999052847-A1 | PHOSPHODIESTERASE ISOENZYME DENOMINATED 4 (PDE 4) INHIBITING COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-21 | — | — | WO | disclosed |