Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL73986 | 0.83 | ESR1 (0.32) | — | |
| SCHEMBL59406 | 0.78 | BLM (0.47) | — | |
| SCHEMBL13702468 | 0.78 | BLM (0.33) | — | |
| SCHEMBL163221 | 0.78 | BLM (0.47) | — | |
| SCHEMBL59405 | 0.78 | BLM (0.47) | — | |
| Hydrochloric Acid SCHEMBL2808246 | 0.77 | BLM (0.46) | — | |
| Hydrochloric Acid SCHEMBL14832457 | 0.77 | BLM (0.46) | — | |
| SCHEMBL502258 | 0.75 | — | — | |
| SCHEMBL13224537 | 0.75 | MEN1 (0.39) | — | |
| SCHEMBL19401021 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0482183-A1 | NOVEL HISTAMINE H 3?-RECEPTOR AGONIST COMPOUNDS FOR THERAPEUTIC USE, PHARMACEUTICAL COMPOSITIONS ACTING AS AGONISTS OF SAID RECEPTOR AND METHOD OF PREPARATION. | INST NAT SANTE RECH MED (FR) | 1992-04-29 | — | — | EP | claimed |
| EP-0655914-B1 | Use of Histamine-2 agonists for treatment of sexual dysfunction | NAHOUM CESAR ROBERTO DIAS (BR) | 2003-02-26 | — | — | EP | disclosed |
| US-5952361-A | Compositions | DIAS NAHOUM CESAR ROBERTO (US) | 1999-09-14 | — | — | US | disclosed |
| US-5908853-A | THERAPY FOR SEXUAL DISORDERS | Nahoum, Cesar Roberto Dias (BR) | 1999-06-01 | — | — | US | disclosed |
| US-5773457-A | Compositions | Nahoum, Cesar Roberto Dias (BR) | 1998-06-30 | — | — | US | disclosed |
| EP-0655914-A4 | NOVEL COMPOSITIONS. | NAHOUM CESAR ROBERTO DIAS (BR) | 1998-04-22 | — | — | EP | disclosed |
| EP-0482183-B1 | HISTAMINE H3-RECEPTOR AGONIST COMPOUNDS FOR THERAPEUTIC USE, PHARMACEUTICAL COMPOSITIONS ACTING AS AGONISTS OF SAID RECEPTOR AND METHOD OF PREPARATION | INST NAT SANTE RECH MED (FR) | 1997-07-30 | — | — | EP | disclosed |
| EP-0655914-A1 | NOVEL COMPOSITIONS | NAHOUM, Cesar Roberto Dias (BR) | 1995-06-07 | — | — | EP | disclosed |
| US-5342960-A | Azomethines agonist compounds of the histamine H3 receptor for therapeutic use, pharmaceutical compositions acting as agonists of the said receptor and preparation process | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1994-08-30 | — | — | US | disclosed |
| WO-1994004120-A2 | METHODS OF TREATING SEXUAL DYSFUNCTION IN ANIMALS WITH AND H AGONIST | NAHOUM CESAR ROBERTO DIAS (BR) | 1994-03-03 | — | — | WO | disclosed |
| EP-0214058-B1 | PHARMACEUTICAL COMPOSITION CONTAINING HISTAMINE DERIVATIVES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1992-05-06 | — | — | EP | disclosed |
| EP-0482183-A1 | NOVEL HISTAMINE H 3?-RECEPTOR AGONIST COMPOUNDS FOR THERAPEUTIC USE, PHARMACEUTICAL COMPOSITIONS ACTING AS AGONISTS OF SAID RECEPTOR AND METHOD OF PREPARATION. | INST NAT SANTE RECH MED (FR) | 1992-04-29 | — | — | EP | disclosed |
| WO-1991017146-A1 | NOVEL HISTAMINE H3-RECEPTOR AGONIST COMPOUNDS FOR THERAPEUTIC USE, PHARMACEUTICAL COMPOSITIONS ACTING AS AGONISTS OF SAID RECEPTOR AND METHOD OF PREPARATION | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1991-11-14 | — | — | WO | disclosed |
| US-4767778-A | HISTAMINE DERIVATIVES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1988-08-30 | — | — | US | disclosed |