Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 11/20 | 0.56 |
| ▸ | ATP4A | P20648 | 2/20 | 0.32 |
| ▸ | ATP4B | P51164 | 2/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039640 | 0.87 | LSS (0.54) | LSS | |
| SCHEMBL7168583 | 0.86 | LSS (0.53) | LSSATP4AATP4BCTSSCTSK | |
| SCHEMBL5038473 | 0.86 | LSS (0.55) | LSS | |
| SCHEMBL7164733 | 0.84 | LSS (0.51) | LSSATP4AATP4BCTSSCTSK | |
| SCHEMBL7167049 | 0.84 | LSS (0.56) | LSSATP4AATP4BCTSSCTSK | |
| SCHEMBL5038808 | 0.83 | LSS (0.81) | LSS | |
| SCHEMBL5039521 | 0.81 | LSS (0.66) | LSSATP4AATP4B | |
| SCHEMBL7166235 | 0.81 | LSS (0.43) | LSS | |
| SCHEMBL5040354 | 0.79 | LSS (0.58) | LSS | |
| SCHEMBL5035559 | 0.79 | LSS (0.58) | LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334094-A1 | CHOLESTEROL LOWERING BENZO[B]THIOPHENES AND BENZO[D]ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002036584-A1 | CHOLESTEROL LOWERING BENZO`B! THIOPHENES AND BENZO`D! ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-10 | — | — | WO | disclosed |