Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | STAT3 | P40763 | 1/20 | 0.54 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8115811 | 0.85 | MAPT (0.71) | MAPTRAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL25056997 | 0.83 | GAA (0.67) | MAPTRAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL10799374 | 0.82 | GAA (0.72) | MAPTRAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL8609704 | 0.81 | MAPT (0.62) | MAPTRAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL27636062 | 0.81 | KMT2A (0.42) | MAPTRAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL116088 | 0.81 | GAA (0.70) | MAPTRAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL29392652 | 0.81 | GAA (0.67) | MAPTRAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL112411 | 0.81 | GAA (0.67) | MAPTRAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL7191668 | 0.80 | PTGER4 (0.49) | MAPTRAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL8612145 | 0.80 | MAPT (0.63) | MAPTRAB9ASMN1; SMN2NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |
| EP-1196391-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005770-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-01-25 | — | — | WO | disclosed |