Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.48 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.39 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7180320 | 1.00 | PTPN1 (0.48) | PTPN1SLC5A1SLC5A2ADRB2ADRB1 | |
| SCHEMBL7178847 | 0.89 | PTPN1 (0.54) | PTPN1SLC5A1SLC5A2ADRB2ADRB1 | |
| SCHEMBL7192289 | 0.89 | PTPN1 (0.54) | PTPN1SLC5A1SLC5A2ADRB2ADRB1 | |
| SCHEMBL7186397 | 0.88 | PTPN1 (0.46) | PTPN1SLC5A1SLC5A2ADRB2ADRB1 | |
| SCHEMBL7177696 | 0.88 | PTPN1 (0.46) | PTPN1SLC5A1SLC5A2ADRB2ADRB1 | |
| SCHEMBL7186033 | 0.88 | PTPN1 (0.55) | PTPN1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL7177324 | 0.88 | PTPN1 (0.55) | PTPN1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL7802499 | 0.87 | PTPN1 (0.47) | PTPN1MAOBMAPTKDM4ELMNA | |
| SCHEMBL7180063 | 0.87 | PTPN1 (0.47) | PTPN1MAOBMAPTKDM4ELMNA | |
| SCHEMBL7191961 | 0.85 | PTPN1 (0.46) | PTPN1MAOBMAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6603046-B1 | The invention is drawn to novel bis-aromatic a, beta -unsaturated ketones. The compounds are useful in the treatment and prophylaxis of diseases caused by parasites or bacteria. | LICA PHARMACEUTICALS A/S (DK) | 2003-08-05 | — | — | US | claimed |
| EP-0634927-B1 | TREATMENT AND PROPHYLAXIS OF DISEASES CAUSED BY PARASITES, OR BACTERIA | LICA PHARMACEUTICALS AS (DK) | 2001-07-04 | — | — | EP | claimed |